Liver transplantation in transthyretin amyloidosis: Issues and challenges
نویسندگان
چکیده
منابع مشابه
Liver transplantation and transthyretin amyloidosis.
Liver transplantation as a specific treatment of transthyretin amyloidosis was first performed in 1990. The rationale for this treatment was that removal of the source (liver) of the amyloid precursor protein (mutated transthyretin) would stop progression of the disease. Indeed, after orthotopic liver transplantation (OLT), mutant transthyretin (TTR) is rapidly cleared from circulation. In the ...
متن کاملSuccessful heart and liver transplantation in a Swiss patient with Glu89Lys transthyretin amyloidosis.
LLS for small babies, especially when the graft has multiple hepatic veins. Seisuke Sakamoto Takanobu Shigeta Ikumi Hamano Akinari Fukuda Toshihiko Kakiuchi Naoto Matsuno Hideaki Tanaka Atsuko Nakagawa Mureo Kasahara 1 Division of Transplant Surgery National Center for Child Health and Development Tokyo, Japan 2 Division of Pediatric Surgery National Center for Child Health and Development Toky...
متن کاملImpact of liver transplantation on transthyretin-related ocular amyloidosis in Japanese patients.
OBJECTIVE To evaluate the long-term impact of liver transplantation on ocular manifestations of familial amyloid polyneuropathy (FAP) in Japanese patients. METHODS Medical records were retrospectively reviewed in a long-term follow-up study. Of 52 patients with FAP amyloidogenic transthyretin Val30Met, 22 patients underwent liver transplantation. We assessed ocular manifestations, including a...
متن کاملOutcome of gastric emptying and gastrointestinal symptoms after liver transplantation for hereditary transthyretin amyloidosis
BACKGROUND Hereditary transthyretin amyloid (ATTR) amyloidosis is a rare but fatal autosomal dominant condition that is present all over the world. A liver transplantation has been shown to halt the progress of the disease in selected patients and is currently considered to be the standard treatment. Gastrointestinal manifestations are common in hereditary ATTR amyloidosis and are important for...
متن کاملPrediction of long-term survival after liver transplantation for familial transthyretin amyloidosis.
Spanish Ministry of Economy and Competitiveness (grant N BFU 2012-36241) and Programa INNPACTO (grant N IPT-2011-0817-010000) (to Dr. Martin), and from the Agence Nationale de la Recherche (Programme Blanc BCNCT) (to Dr. Lambert). Dr. Alves was a recipient of a PhD grant SFRH/BD/27990/2006 and research grant PTDC/SAU-GMG/101874/2008 from FCT. Mrs. Medeiros was supported by a research grant from...
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ژورنال
عنوان ژورنال: Liver Transplantation
سال: 2015
ISSN: 1527-6465
DOI: 10.1002/lt.24058